Drug interactions
Linezolid + Trimipramine
Severity: Major
Linezolid and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as trimipramine inhibit monoamine reuptake, and linezolid inhibits MAO. The combination raises the risk of serotonin syndrome and noradrenergic excess.
What this interaction means in plain words
Linezolid and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Trimipramine belongs to Central Nervous System.
Why it happens
Reuptake inhibition combined with MAO inhibition increases synaptic monoamines.
What to do
Avoid if an alternative antibiotic exists. If linezolid is necessary, monitor for serotonin toxicity and consider temporarily stopping the tricyclic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Linezolid with Trimipramine?
MediHelp rates the interaction as major. Linezolid and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants such as trimipramine inhibit monoamine reuptake, and linezolid inhibits MAO. The combination raises the risk of serotonin syndrome and noradrenergic excess.
How serious is the interaction between Linezolid and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antibiotic exists. If linezolid is necessary, monitor for serotonin toxicity and consider temporarily stopping the tricyclic.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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