Drug interactions
Linezolid + Valbenazine
Severity: Major
Linezolid and Valbenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine inhibits VMAT2, and MAO inhibitors alter monoamine breakdown. Combining them may disturb monoamine balance, raising the risk of serotonin syndrome or blunting valbenazine's effect.
What this interaction means in plain words
Linezolid and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Valbenazine belongs to Central Nervous System.
Why it happens
Opposing effects on monoamine handling, VMAT2 inhibition versus MAO inhibition; the clinical mechanism is theoretical.
What to do
Avoid concurrent use; consider an alternative antibiotic or delay valbenazine during linezolid therapy. If both are given, monitor for serotonin toxicity and loss of valbenazine effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Linezolid with Valbenazine?
MediHelp rates the interaction as major. Linezolid and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valbenazine inhibits VMAT2, and MAO inhibitors alter monoamine breakdown. Combining them may disturb monoamine balance, raising the risk of serotonin syndrome or blunting valbenazine's effect.
How serious is the interaction between Linezolid and Valbenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; consider an alternative antibiotic or delay valbenazine during linezolid therapy. If both are given, monitor for serotonin toxicity and loss of valbenazine effect.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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