Drug interactions
Liothyronine + Metformin-pioglitazone
Severity: Moderate
Liothyronine and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone increases hepatic glucose output and metabolic rate, which can raise glucose and reduce the effect of antidiabetic drugs. Changes in thyroid dose can therefore alter glycemic control.
What this interaction means in plain words
Liothyronine and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liothyronine belongs to Endocrine; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Thyroid hormone enhances gluconeogenesis, glycogenolysis and glucose absorption, opposing antidiabetic effects.
What to do
Monitor blood glucose when starting or adjusting liothyronine and adjust antidiabetic doses as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Liothyronine with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Liothyronine and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone increases hepatic glucose output and metabolic rate, which can raise glucose and reduce the effect of antidiabetic drugs. Changes in thyroid dose can therefore alter glycemic control.
How serious is the interaction between Liothyronine and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting liothyronine and adjust antidiabetic doses as required.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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