Drug interactions
Liothyronine + Nortriptyline
Severity: Moderate
Liothyronine and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone can enhance the cardiac and CNS stimulating effects of tricyclic antidepressants. This may increase the chance of tachycardia, arrhythmias and agitation, particularly at higher thyroid doses. Thyroid hormone is also sometimes used deliberately to augment antidepressant response.
What this interaction means in plain words
Liothyronine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liothyronine belongs to Endocrine; Nortriptyline belongs to Central Nervous System.
Why it happens
Thyroid hormone increases sensitivity of adrenergic receptors, which adds to the noradrenergic effects of the TCA.
What to do
Monitor heart rate, rhythm and thyroid function, and use ECG monitoring in patients with cardiac disease. Adjust doses if palpitations or arrhythmias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Liothyronine with Nortriptyline?
MediHelp rates the interaction as moderate. Liothyronine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone can enhance the cardiac and CNS stimulating effects of tricyclic antidepressants. This may increase the chance of tachycardia, arrhythmias and agitation, particularly at higher thyroid doses. Thyroid hormone is also sometimes used deliberately to augment antidepressant response.
How serious is the interaction between Liothyronine and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and thyroid function, and use ECG monitoring in patients with cardiac disease. Adjust doses if palpitations or arrhythmias occur.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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