Drug interactions
Liposomal doxorubicin + Lonafarnib
Severity: Minor
Liposomal doxorubicin and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate and a CYP3A4 inhibitor, while doxorubicin has weak CYP3A4 effects, so a large interaction is unlikely. Both drugs may affect cardiac conduction or function, which adds some theoretical concern.
What this interaction means in plain words
Liposomal doxorubicin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liposomal doxorubicin belongs to Oncology; Lonafarnib belongs to Miscellaneous.
Why it happens
Doxorubicin is not a recognized CYP3A4 inhibitor; any effect on lonafarnib exposure is unestablished.
What to do
Monitor ECG and cardiac function and watch for lonafarnib adverse effects such as gastrointestinal toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Liposomal doxorubicin with Lonafarnib?
MediHelp rates the interaction as minor. Liposomal doxorubicin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A4 substrate and a CYP3A4 inhibitor, while doxorubicin has weak CYP3A4 effects, so a large interaction is unlikely. Both drugs may affect cardiac conduction or function, which adds some theoretical concern.
How serious is the interaction between Liposomal doxorubicin and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and cardiac function and watch for lonafarnib adverse effects such as gastrointestinal toxicity.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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