Drug interactions
Liposomal doxorubicin + Pomalidomide
Severity: Minor
Liposomal doxorubicin and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is a P-gp substrate, but doxorubicin is not a recognized P-gp inhibitor strong enough to alter its exposure. The pair is commonly used together in myeloma regimens, with additive myelosuppression the practical concern.
What this interaction means in plain words
Liposomal doxorubicin and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liposomal doxorubicin belongs to Oncology; Pomalidomide belongs to Miscellaneous.
Why it happens
No established pharmacokinetic mechanism; additive myelosuppression is a pharmacodynamic overlap.
What to do
Monitor complete blood counts and adjust doses of either drug for neutropenia or thrombocytopenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Liposomal doxorubicin with Pomalidomide?
MediHelp rates the interaction as minor. Liposomal doxorubicin and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide is a P-gp substrate, but doxorubicin is not a recognized P-gp inhibitor strong enough to alter its exposure. The pair is commonly used together in myeloma regimens, with additive myelosuppression the practical concern.
How serious is the interaction between Liposomal doxorubicin and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and adjust doses of either drug for neutropenia or thrombocytopenia.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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