Drug interactions
Liposomal doxorubicin + Ribociclib
Severity: Moderate
Liposomal doxorubicin and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and P-gp, which could raise doxorubicin exposure. Both agents cause myelosuppression and ribociclib prolongs QT, so additive toxicity is plausible, though the pharmacokinetic effect is likely small.
What this interaction means in plain words
Liposomal doxorubicin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib weakly to moderately inhibits CYP3A4 and P-gp, and both drugs have additive myelosuppressive effects.
What to do
Monitor complete blood counts and ECG/electrolytes, and watch for increased doxorubicin toxicity including cardiac effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Liposomal doxorubicin with Ribociclib?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and P-gp, which could raise doxorubicin exposure. Both agents cause myelosuppression and ribociclib prolongs QT, so additive toxicity is plausible, though the pharmacokinetic effect is likely small.
How serious is the interaction between Liposomal doxorubicin and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and ECG/electrolytes, and watch for increased doxorubicin toxicity including cardiac effects.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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