Drug interactions
Liposomal doxorubicin + Tacrolimus
Severity: Moderate
Liposomal doxorubicin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus inhibits P-glycoprotein and could raise doxorubicin exposure. Both can be toxic, tacrolimus to the kidney and doxorubicin to the heart and marrow, and the patient is also immunosuppressed.
What this interaction means in plain words
Liposomal doxorubicin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Tacrolimus inhibits P-glycoprotein efflux, potentially increasing doxorubicin concentrations; additive immunosuppression also occurs.
What to do
Monitor blood counts, cardiac function and infection signs, and check tacrolimus trough levels and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Liposomal doxorubicin with Tacrolimus?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus inhibits P-glycoprotein and could raise doxorubicin exposure. Both can be toxic, tacrolimus to the kidney and doxorubicin to the heart and marrow, and the patient is also immunosuppressed.
How serious is the interaction between Liposomal doxorubicin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, cardiac function and infection signs, and check tacrolimus trough levels and renal function.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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