Drug interactions
Liposomal doxorubicin + Tipranavir
Severity: Moderate
Liposomal doxorubicin and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted tipranavir has mixed CYP3A4 inhibiting and inducing effects and affects P-gp, so doxorubicin exposure may change unpredictably. Increased toxicity is the main concern.
What this interaction means in plain words
Liposomal doxorubicin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Tipranavir belongs to Anti Virals.
Why it happens
Tipranavir with ritonavir modulates CYP3A4 and P-glycoprotein, altering doxorubicin clearance.
What to do
Monitor blood counts and cardiac function and adjust the doxorubicin dose to toxicity. Consider an alternative antiretroviral.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Liposomal doxorubicin with Tipranavir?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted tipranavir has mixed CYP3A4 inhibiting and inducing effects and affects P-gp, so doxorubicin exposure may change unpredictably. Increased toxicity is the main concern.
How serious is the interaction between Liposomal doxorubicin and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function and adjust the doxorubicin dose to toxicity. Consider an alternative antiretroviral.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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