Drug interactions
Liposomal doxorubicin + Trastuzumab deruxtecan
Severity: Major
Liposomal doxorubicin and Trastuzumab deruxtecan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab-based therapies can cause left ventricular dysfunction, and the risk is higher with anthracyclines. Liposomal doxorubicin is less cardiotoxic than conventional doxorubicin but still carries risk, so combined cardiac injury is possible.
What this interaction means in plain words
Liposomal doxorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Liposomal doxorubicin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive cardiotoxicity from anthracycline myocardial injury and HER2 inhibition.
What to do
Avoid combining where possible and account for cumulative anthracycline dose. If used together, assess LVEF before and periodically during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Liposomal doxorubicin with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Liposomal doxorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab-based therapies can cause left ventricular dysfunction, and the risk is higher with anthracyclines. Liposomal doxorubicin is less cardiotoxic than conventional doxorubicin but still carries risk, so combined cardiac injury is possible.
How serious is the interaction between Liposomal doxorubicin and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and account for cumulative anthracycline dose. If used together, assess LVEF before and periodically during treatment.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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