Drug interactions
Liposomal doxorubicin + Voriconazole
Severity: Minor
Liposomal doxorubicin and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and may modestly raise doxorubicin exposure. Because CYP3A4 is a minor pathway for doxorubicin, the effect is probably limited, though toxicity may increase.
What this interaction means in plain words
Liposomal doxorubicin and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liposomal doxorubicin belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
CYP3A4 and possibly P-glycoprotein inhibition by voriconazole may reduce doxorubicin clearance.
What to do
No empirical dose change; monitor blood counts, mucositis and cardiac function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Liposomal doxorubicin with Voriconazole?
MediHelp rates the interaction as minor. Liposomal doxorubicin and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole inhibits CYP3A4 and may modestly raise doxorubicin exposure. Because CYP3A4 is a minor pathway for doxorubicin, the effect is probably limited, though toxicity may increase.
How serious is the interaction between Liposomal doxorubicin and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor blood counts, mucositis and cardiac function.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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