Drug interactions
Liraglutide + Perphenazine
Severity: Minor
Liraglutide and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can change glucose handling and may raise or lower blood glucose, potentially counteracting the glycemic effect of liraglutide. The interaction is variable and poorly quantified.
What this interaction means in plain words
Liraglutide and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liraglutide belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition from antipsychotic effects on glucose metabolism; the mechanism is not well established.
What to do
Monitor blood glucose and HbA1c after starting or stopping perphenazine. Adjust the antidiabetic regimen if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Perphenazine?
MediHelp rates the interaction as minor. Liraglutide and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines can change glucose handling and may raise or lower blood glucose, potentially counteracting the glycemic effect of liraglutide. The interaction is variable and poorly quantified.
How serious is the interaction between Liraglutide and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping perphenazine. Adjust the antidiabetic regimen if control changes.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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