Drug interactions
Liraglutide + Saxagliptin
Severity: Moderate
Liraglutide and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
GLP-1 receptor agonists and DPP-4 inhibitors act on the same incretin pathway, so combining them offers little added glycemic benefit. Hypoglycemia risk is low unless insulin or a sulfonylurea is also used.
What this interaction means in plain words
Liraglutide and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liraglutide belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
Overlapping incretin pathway effects: liraglutide activates GLP-1 receptors while saxagliptin prevents breakdown of endogenous GLP-1.
What to do
Generally avoid the combination because of limited added benefit. If used, monitor glucose and reduce any concurrent sulfonylurea or insulin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liraglutide
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Liraglutide with Saxagliptin?
MediHelp rates the interaction as moderate. Liraglutide and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. GLP-1 receptor agonists and DPP-4 inhibitors act on the same incretin pathway, so combining them offers little added glycemic benefit. Hypoglycemia risk is low unless insulin or a sulfonylurea is also used.
How serious is the interaction between Liraglutide and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally avoid the combination because of limited added benefit. If used, monitor glucose and reduce any concurrent sulfonylurea or insulin dose.
What other medicines interact with Liraglutide?
MediHelp also lists interactions of Liraglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Liraglutide page.
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