Drug interactions
Lisdexamfetamine + Lorazepam
Severity: Minor
Lisdexamfetamine and Lorazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine is a stimulant prodrug of dextroamphetamine, and its stimulating effects oppose lorazepam sedation. The net effect is unpredictable and stimulation may mask impairment.
What this interaction means in plain words
Lisdexamfetamine and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisdexamfetamine belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic interaction.
What to do
No routine dose change is needed. Monitor for both excess sedation and anxiety or insomnia, and counsel on driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lisdexamfetamine and Lorazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lorazepam
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Lorazepam?
MediHelp rates the interaction as minor. Lisdexamfetamine and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lisdexamfetamine is a stimulant prodrug of dextroamphetamine, and its stimulating effects oppose lorazepam sedation. The net effect is unpredictable and stimulation may mask impairment.
How serious is the interaction between Lisdexamfetamine and Lorazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for both excess sedation and anxiety or insomnia, and counsel on driving.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
