Drug interactions
Lisdexamfetamine + Nateglinide
Severity: Minor
Lisdexamfetamine and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stimulants can alter glucose regulation and may reduce the glucose-lowering effect of antidiabetic drugs. Appetite suppression from lisdexamfetamine may in contrast increase hypoglycemia risk with a secretagogue like nateglinide. The net effect is variable and generally modest.
What this interaction means in plain words
Lisdexamfetamine and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisdexamfetamine belongs to Central Nervous System; Nateglinide belongs to Endocrine.
Why it happens
Sympathomimetic effects on glucose metabolism oppose insulin secretagogue action; reduced food intake may offset this.
What to do
Monitor blood glucose when starting or stopping lisdexamfetamine. Adjust the nateglinide dose according to readings and meal patterns.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lisdexamfetamine and Nateglinide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Lisdexamfetamine with Nateglinide?
MediHelp rates the interaction as minor. Lisdexamfetamine and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stimulants can alter glucose regulation and may reduce the glucose-lowering effect of antidiabetic drugs. Appetite suppression from lisdexamfetamine may in contrast increase hypoglycemia risk with a secretagogue like nateglinide. The net effect is variable and generally modest.
How serious is the interaction between Lisdexamfetamine and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping lisdexamfetamine. Adjust the nateglinide dose according to readings and meal patterns.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
