Drug interactions
Lisdexamfetamine + Oxazepam
Severity: Minor
Lisdexamfetamine and Oxazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A stimulant and a sedative have opposing effects on arousal, and the net result is unpredictable. Stimulation may mask sedation without removing the psychomotor impairment.
What this interaction means in plain words
Lisdexamfetamine and Oxazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisdexamfetamine belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no significant pharmacokinetic interaction is established.
What to do
No routine dose change is needed. Review the ongoing need for each drug and do not rely on the stimulant to offset benzodiazepine sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lisdexamfetamine and Oxazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Oxazepam?
MediHelp rates the interaction as minor. Lisdexamfetamine and Oxazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A stimulant and a sedative have opposing effects on arousal, and the net result is unpredictable. Stimulation may mask sedation without removing the psychomotor impairment.
How serious is the interaction between Lisdexamfetamine and Oxazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Review the ongoing need for each drug and do not rely on the stimulant to offset benzodiazepine sedation.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
