Drug interactions
Lisdexamfetamine + Selegiline
Severity: Contraindicated
Lisdexamfetamine and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline inhibits MAO-B and, at higher doses or transdermally, MAO-A, reducing amphetamine breakdown and increasing monoamine accumulation. Hypertensive crisis and serotonin syndrome may occur. Use is contraindicated.
What this interaction means in plain words
Lisdexamfetamine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lisdexamfetamine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
MAO inhibition potentiates amphetamine-induced monoamine release.
What to do
Do not combine, and allow 14 days after selegiline before lisdexamfetamine. Use a non-stimulant alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Selegiline?
MediHelp rates the interaction as contraindicated. Lisdexamfetamine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline inhibits MAO-B and, at higher doses or transdermally, MAO-A, reducing amphetamine breakdown and increasing monoamine accumulation. Hypertensive crisis and serotonin syndrome may occur. Use is contraindicated.
How serious is the interaction between Lisdexamfetamine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine, and allow 14 days after selegiline before lisdexamfetamine. Use a non-stimulant alternative.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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