Drug interactions
Lisdexamfetamine + Salmeterol
Severity: Moderate
Lisdexamfetamine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase sympathetic activity, and salmeterol adds beta-agonist cardiac effects. The combination may increase heart rate, blood pressure and risk of palpitations or arrhythmia.
What this interaction means in plain words
Lisdexamfetamine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive sympathomimetic cardiovascular stimulation.
What to do
Monitor heart rate and blood pressure, particularly in patients with cardiovascular disease, and reduce doses if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Salmeterol?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase sympathetic activity, and salmeterol adds beta-agonist cardiac effects. The combination may increase heart rate, blood pressure and risk of palpitations or arrhythmia.
How serious is the interaction between Lisdexamfetamine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, particularly in patients with cardiovascular disease, and reduce doses if symptoms develop.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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