Drug interactions
Lixisenatide + Tolbutamide
Severity: Moderate
Lixisenatide and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lixisenatide stimulates glucose-dependent insulin secretion, and combined with a sulfonylurea the risk of hypoglycemia is higher. A sulfonylurea dose reduction is often needed.
What this interaction means in plain words
Lixisenatide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lixisenatide belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive insulinotropic effect of a GLP-1 receptor agonist and a sulfonylurea.
What to do
Consider reducing the tolbutamide dose when lixisenatide is started. Monitor blood glucose frequently during titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Lixisenatide
Frequently asked questions
Can I take Lixisenatide with Tolbutamide?
MediHelp rates the interaction as moderate. Lixisenatide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lixisenatide stimulates glucose-dependent insulin secretion, and combined with a sulfonylurea the risk of hypoglycemia is higher. A sulfonylurea dose reduction is often needed.
How serious is the interaction between Lixisenatide and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolbutamide dose when lixisenatide is started. Monitor blood glucose frequently during titration.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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