Drug interactions
Lofexidine + Naltrexone
Severity: Moderate
Lofexidine and Naltrexone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral naltrexone exposure was altered when given with lofexidine in pharmacokinetic testing, and labeling suggests its efficacy may be reduced. The effect is mainly relevant to oral naltrexone given close in time to lofexidine.
What this interaction means in plain words
Lofexidine and Naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Naltrexone belongs to Musculoskeletal.
Why it happens
The mechanism is not established; lofexidine alters the steady-state pharmacokinetics of oral naltrexone.
What to do
Separate oral naltrexone from lofexidine by at least 2 hours, and monitor for reduced naltrexone effect. Injectable naltrexone is not expected to be affected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naltrexone
- Naldemedine + Naltrexone Major
- Naloxegol + Naltrexone Major
- Bremelanotide + Naltrexone Moderate
- Acamprosate + Naltrexone Minor
- Apalutamide + Naltrexone Minor
- Dronabinol + Naltrexone Minor
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Naltrexone?
MediHelp rates the interaction as moderate. Lofexidine and Naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral naltrexone exposure was altered when given with lofexidine in pharmacokinetic testing, and labeling suggests its efficacy may be reduced. The effect is mainly relevant to oral naltrexone given close in time to lofexidine.
How serious is the interaction between Lofexidine and Naltrexone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral naltrexone from lofexidine by at least 2 hours, and monitor for reduced naltrexone effect. Injectable naltrexone is not expected to be affected.
What other medicines interact with Naltrexone?
MediHelp also lists interactions of Naltrexone with, for example, Naldemedine, Naloxegol, Bremelanotide. The full list is on the Naltrexone page.
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