Drug interactions
Dronabinol + Naltrexone
Severity: Minor
Dronabinol and Naltrexone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no well-established pharmacokinetic interaction, and any pharmacodynamic effect is speculative. Opioid antagonism has been reported to modify some cannabinoid effects, but clinical significance is unclear.
What this interaction means in plain words
Dronabinol and Naltrexone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronabinol belongs to Central Nervous System; Naltrexone belongs to Musculoskeletal.
Why it happens
Mechanism not firmly established; possible interplay between opioid and cannabinoid signaling pathways.
What to do
No routine adjustment is needed; monitor for changes in dronabinol effect such as appetite, nausea control or mood.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naltrexone
- Naldemedine + Naltrexone Major
- Naloxegol + Naltrexone Major
- Bremelanotide + Naltrexone Moderate
- Lofexidine + Naltrexone Moderate
- Acamprosate + Naltrexone Minor
- Apalutamide + Naltrexone Minor
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Naltrexone?
MediHelp rates the interaction as minor. Dronabinol and Naltrexone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no well-established pharmacokinetic interaction, and any pharmacodynamic effect is speculative. Opioid antagonism has been reported to modify some cannabinoid effects, but clinical significance is unclear.
How serious is the interaction between Dronabinol and Naltrexone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for changes in dronabinol effect such as appetite, nausea control or mood.
What other medicines interact with Naltrexone?
MediHelp also lists interactions of Naltrexone with, for example, Naldemedine, Naloxegol, Bremelanotide. The full list is on the Naltrexone page.
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