Drug interactions
Apalutamide + Naltrexone
Severity: Minor
Apalutamide and Naltrexone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an enzyme inducer and may modestly lower naltrexone and its active metabolite exposure. Reduced opioid blockade could lessen the effectiveness of naltrexone, though the clinical impact is uncertain since naltrexone is mainly cleared by non-CYP reduction.
What this interaction means in plain words
Apalutamide and Naltrexone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Naltrexone belongs to Musculoskeletal.
Why it happens
Enzyme induction by apalutamide, including UGT, may speed clearance of naltrexone metabolites; effect on parent drug is not well established.
What to do
Monitor for reduced naltrexone efficacy, such as craving or return to use. Consider dose review if response is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naltrexone
- Naldemedine + Naltrexone Major
- Naloxegol + Naltrexone Major
- Bremelanotide + Naltrexone Moderate
- Lofexidine + Naltrexone Moderate
- Acamprosate + Naltrexone Minor
- Dronabinol + Naltrexone Minor
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Naltrexone?
MediHelp rates the interaction as minor. Apalutamide and Naltrexone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide is an enzyme inducer and may modestly lower naltrexone and its active metabolite exposure. Reduced opioid blockade could lessen the effectiveness of naltrexone, though the clinical impact is uncertain since naltrexone is mainly cleared by non-CYP reduction.
How serious is the interaction between Apalutamide and Naltrexone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced naltrexone efficacy, such as craving or return to use. Consider dose review if response is lost.
What other medicines interact with Naltrexone?
MediHelp also lists interactions of Naltrexone with, for example, Naldemedine, Naloxegol, Bremelanotide. The full list is on the Naltrexone page.
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