Drug interactions
Naloxegol + Naltrexone
Severity: Major
Naloxegol and Naltrexone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naltrexone blocks opioid receptors systemically, and naloxegol adds peripheral antagonism, increasing the chance of opioid withdrawal and reducing opioid effect in patients exposed to opioids.
What this interaction means in plain words
Naloxegol and Naltrexone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Naloxegol belongs to Gastrointestinal Tract; Naltrexone belongs to Musculoskeletal.
Why it happens
Additive opioid receptor antagonism.
What to do
Avoid concurrent use and use a conventional laxative for constipation instead. If opioids are being taken, monitor for withdrawal symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Naltrexone
- Naldemedine + Naltrexone Major
- Bremelanotide + Naltrexone Moderate
- Lofexidine + Naltrexone Moderate
- Acamprosate + Naltrexone Minor
- Apalutamide + Naltrexone Minor
- Dronabinol + Naltrexone Minor
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Naloxegol with Naltrexone?
MediHelp rates the interaction as major. Naloxegol and Naltrexone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Naltrexone blocks opioid receptors systemically, and naloxegol adds peripheral antagonism, increasing the chance of opioid withdrawal and reducing opioid effect in patients exposed to opioids.
How serious is the interaction between Naloxegol and Naltrexone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and use a conventional laxative for constipation instead. If opioids are being taken, monitor for withdrawal symptoms.
What other medicines interact with Naltrexone?
MediHelp also lists interactions of Naltrexone with, for example, Naldemedine, Bremelanotide, Lofexidine. The full list is on the Naltrexone page.
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