Drug interactions
Lomitapide + Loperamide
Severity: Minor
Lomitapide and Loperamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein, which limits loperamide absorption and CNS entry. Higher loperamide exposure may increase constipation and central opioid effects, and at high exposures can contribute to QT prolongation.
What this interaction means in plain words
Lomitapide and Loperamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lomitapide belongs to Cardiovascular; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Lomitapide inhibits P-glycoprotein efflux of loperamide, raising its systemic and CNS exposure.
What to do
Use the lowest effective loperamide dose and do not exceed labeled limits. Reduce the dose or stop it if constipation, dizziness or palpitations occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loperamide
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Loperamide?
MediHelp rates the interaction as minor. Lomitapide and Loperamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide inhibits P-glycoprotein, which limits loperamide absorption and CNS entry. Higher loperamide exposure may increase constipation and central opioid effects, and at high exposures can contribute to QT prolongation.
How serious is the interaction between Lomitapide and Loperamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective loperamide dose and do not exceed labeled limits. Reduce the dose or stop it if constipation, dizziness or palpitations occur.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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