Drug interactions
Lomitapide + Lurasidone
Severity: Moderate
Lomitapide and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone is a weak CYP3A4 inhibitor in vitro, and lomitapide is a CYP3A4 substrate, so lomitapide exposure may rise modestly. Higher lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. Clinical evidence for lurasidone specifically is limited.
What this interaction means in plain words
Lomitapide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Possible weak inhibition of CYP3A4 by lurasidone reduces lomitapide metabolism.
What to do
Monitor liver enzymes and gastrointestinal tolerability, and keep the lomitapide dose within labeled limits for patients on weak CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Lurasidone?
MediHelp rates the interaction as moderate. Lomitapide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone is a weak CYP3A4 inhibitor in vitro, and lomitapide is a CYP3A4 substrate, so lomitapide exposure may rise modestly. Higher lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. Clinical evidence for lurasidone specifically is limited.
How serious is the interaction between Lomitapide and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerability, and keep the lomitapide dose within labeled limits for patients on weak CYP3A4 inhibitors.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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