Drug interactions
Lomitapide + Mefloquine
Severity: Moderate
Lomitapide and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine may raise lomitapide exposure through CYP3A4 inhibition, which increases the risk of hepatotoxicity and gastrointestinal effects. Lomitapide is highly sensitive to CYP3A4 inhibition.
What this interaction means in plain words
Lomitapide and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4 reduces lomitapide metabolism.
What to do
Monitor liver enzymes and tolerability. Keep lomitapide at or below the labeled limit for weak CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Mefloquine?
MediHelp rates the interaction as moderate. Lomitapide and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine may raise lomitapide exposure through CYP3A4 inhibition, which increases the risk of hepatotoxicity and gastrointestinal effects. Lomitapide is highly sensitive to CYP3A4 inhibition.
How serious is the interaction between Lomitapide and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and tolerability. Keep lomitapide at or below the labeled limit for weak CYP3A4 inhibitors.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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