Drug interactions
Lomitapide + Omeprazole
Severity: Moderate
Lomitapide and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole is at most a weak CYP3A4 inhibitor, which could modestly increase lomitapide exposure. Lomitapide is highly sensitive to CYP3A4 inhibition, with a risk of hepatotoxicity and gastrointestinal effects.
What this interaction means in plain words
Lomitapide and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Possible weak CYP3A4 inhibition by omeprazole increases lomitapide exposure.
What to do
Monitor liver enzymes and gastrointestinal tolerability, and keep lomitapide at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Omeprazole?
MediHelp rates the interaction as moderate. Lomitapide and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omeprazole is at most a weak CYP3A4 inhibitor, which could modestly increase lomitapide exposure. Lomitapide is highly sensitive to CYP3A4 inhibition, with a risk of hepatotoxicity and gastrointestinal effects.
How serious is the interaction between Lomitapide and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerability, and keep lomitapide at the lowest effective dose.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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