Drug interactions
Lomitapide + Paliperidone
Severity: Minor
Lomitapide and Paliperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein, and paliperidone is a P-gp substrate, so paliperidone exposure may rise modestly. This could increase dose-related adverse effects such as sedation, extrapyramidal symptoms or QT prolongation.
What this interaction means in plain words
Lomitapide and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lomitapide belongs to Cardiovascular; Paliperidone belongs to Central Nervous System.
Why it happens
Inhibition of intestinal and renal P-glycoprotein efflux of paliperidone by lomitapide.
What to do
Monitor for paliperidone adverse effects and reduce the dose if they emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Paliperidone?
MediHelp rates the interaction as minor. Lomitapide and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide inhibits P-glycoprotein, and paliperidone is a P-gp substrate, so paliperidone exposure may rise modestly. This could increase dose-related adverse effects such as sedation, extrapyramidal symptoms or QT prolongation.
How serious is the interaction between Lomitapide and Paliperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paliperidone adverse effects and reduce the dose if they emerge.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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