Drug interactions
Lomitapide + Tacrolimus
Severity: Moderate
Lomitapide and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and may increase tacrolimus exposure. Raised tacrolimus levels can cause nephrotoxicity, neurotoxicity and hyperglycemia.
What this interaction means in plain words
Lomitapide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by lomitapide increases tacrolimus absorption and exposure.
What to do
Monitor tacrolimus trough concentrations and renal function after lomitapide is started or its dose changed. Reduce the tacrolimus dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Tacrolimus?
MediHelp rates the interaction as moderate. Lomitapide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide inhibits P-glycoprotein and may increase tacrolimus exposure. Raised tacrolimus levels can cause nephrotoxicity, neurotoxicity and hyperglycemia.
How serious is the interaction between Lomitapide and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations and renal function after lomitapide is started or its dose changed. Reduce the tacrolimus dose if levels rise.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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