Drug interactions
Lomitapide + Voriconazole
Severity: Contraindicated
Lomitapide and Voriconazole: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole greatly increases lomitapide exposure, risking marked hepatotoxicity and gastrointestinal adverse effects.
What this interaction means in plain words
Lomitapide and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lomitapide belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by voriconazole reduces lomitapide metabolism.
What to do
Do not co-administer; hold lomitapide during voriconazole treatment and monitor liver enzymes after restart.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Voriconazole?
MediHelp rates the interaction as contraindicated. Lomitapide and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole greatly increases lomitapide exposure, risking marked hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Lomitapide and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; hold lomitapide during voriconazole treatment and monitor liver enzymes after restart.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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