Drug interactions
Lomustine + Palifermin
Severity: Major
Lomustine and Palifermin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth, which may make rapidly dividing mucosal cells more vulnerable to cytotoxic chemotherapy. When given close to chemotherapy, the severity and duration of oral mucositis increased.
What this interaction means in plain words
Lomustine and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lomustine belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-induced keratinocyte proliferation may sensitize mucosal epithelium to cytotoxic agents.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after lomustine. Follow the labeled schedule of administration around chemotherapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Palifermin
Frequently asked questions
Can I take Lomustine with Palifermin?
MediHelp rates the interaction as major. Lomustine and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palifermin stimulates epithelial cell growth, which may make rapidly dividing mucosal cells more vulnerable to cytotoxic chemotherapy. When given close to chemotherapy, the severity and duration of oral mucositis increased.
How serious is the interaction between Lomustine and Palifermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after lomustine. Follow the labeled schedule of administration around chemotherapy.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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