Drug interactions
Lomustine + Trastuzumab
Severity: Moderate
Lomustine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab given with myelosuppressive chemotherapy has been associated with a higher incidence of neutropenia and febrile neutropenia. Lomustine adds delayed and cumulative marrow suppression, so infection risk may rise.
What this interaction means in plain words
Lomustine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomustine belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive neutropenia when trastuzumab is combined with a myelosuppressive cytotoxic agent; the exact mechanism is not fully established.
What to do
Monitor neutrophil and platelet counts regularly, including at the lomustine nadir. Manage neutropenia per standard protocols and delay or reduce doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Lomustine with Trastuzumab?
MediHelp rates the interaction as moderate. Lomustine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab given with myelosuppressive chemotherapy has been associated with a higher incidence of neutropenia and febrile neutropenia. Lomustine adds delayed and cumulative marrow suppression, so infection risk may rise.
How serious is the interaction between Lomustine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil and platelet counts regularly, including at the lomustine nadir. Manage neutropenia per standard protocols and delay or reduce doses as needed.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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