Drug interactions
Lonafarnib + Lovastatin
Severity: Contraindicated
Lonafarnib and Lovastatin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and is expected to raise lovastatin levels considerably. This increases the risk of statin-related muscle toxicity including rhabdomyolysis.
What this interaction means in plain words
Lonafarnib and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lonafarnib belongs to Miscellaneous; Lovastatin belongs to Cardiovascular.
Why it happens
Strong CYP3A4 inhibition by lonafarnib decreases lovastatin clearance.
What to do
Avoid coadministration; stop lovastatin or substitute a statin not reliant on CYP3A4. Warn the patient about muscle pain, weakness and dark urine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Lovastatin?
MediHelp rates the interaction as contraindicated. Lonafarnib and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a strong CYP3A inhibitor and is expected to raise lovastatin levels considerably. This increases the risk of statin-related muscle toxicity including rhabdomyolysis.
How serious is the interaction between Lonafarnib and Lovastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; stop lovastatin or substitute a statin not reliant on CYP3A4. Warn the patient about muscle pain, weakness and dark urine.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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