Drug interactions
Lonafarnib + Lurasidone
Severity: Contraindicated
Lonafarnib and Lurasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and is itself a sensitive CYP3A substrate, and it can substantially raise lurasidone exposure. Lurasidone is contraindicated with strong CYP3A4 inhibitors because of the risk of excessive adverse effects.
What this interaction means in plain words
Lonafarnib and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lonafarnib belongs to Miscellaneous; Lurasidone belongs to Central Nervous System.
Why it happens
Lonafarnib inhibition of CYP3A4 reduces lurasidone clearance.
What to do
Do not combine; choose an antipsychotic that is not dependent on CYP3A4 metabolism.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Lurasidone?
MediHelp rates the interaction as contraindicated. Lonafarnib and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a strong CYP3A inhibitor and is itself a sensitive CYP3A substrate, and it can substantially raise lurasidone exposure. Lurasidone is contraindicated with strong CYP3A4 inhibitors because of the risk of excessive adverse effects.
How serious is the interaction between Lonafarnib and Lurasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an antipsychotic that is not dependent on CYP3A4 metabolism.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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