Drug interactions
Lonafarnib + Mefloquine
Severity: Moderate
Lonafarnib and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and mefloquine's CYP3A inhibitory effect is uncertain and probably weak. Any increase in lonafarnib exposure could raise its adverse effects, and its cardiac effects are not fully characterized.
What this interaction means in plain words
Lonafarnib and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A inhibition by mefloquine increasing lonafarnib exposure; not firmly established.
What to do
Prefer an alternative antimalarial if possible. If used together, monitor for lonafarnib toxicity such as gastrointestinal effects, and monitor the ECG for arrhythmia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Mefloquine?
MediHelp rates the interaction as moderate. Lonafarnib and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate, and mefloquine's CYP3A inhibitory effect is uncertain and probably weak. Any increase in lonafarnib exposure could raise its adverse effects, and its cardiac effects are not fully characterized.
How serious is the interaction between Lonafarnib and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antimalarial if possible. If used together, monitor for lonafarnib toxicity such as gastrointestinal effects, and monitor the ECG for arrhythmia symptoms.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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