Drug interactions
Lonafarnib + Omeprazole
Severity: Moderate
Lonafarnib and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate and an inhibitor of CYP2C19, so it may raise omeprazole exposure. Omeprazole is only a weak CYP3A inhibitor, so lonafarnib exposure should change little.
What this interaction means in plain words
Lonafarnib and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Lonafarnib inhibits CYP2C19, reducing omeprazole clearance, and omeprazole weakly inhibits CYP3A.
What to do
Monitor for omeprazole adverse effects and consider a lower omeprazole dose. Monitor lonafarnib tolerability, especially GI effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Omeprazole?
MediHelp rates the interaction as moderate. Lonafarnib and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate and an inhibitor of CYP2C19, so it may raise omeprazole exposure. Omeprazole is only a weak CYP3A inhibitor, so lonafarnib exposure should change little.
How serious is the interaction between Lonafarnib and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for omeprazole adverse effects and consider a lower omeprazole dose. Monitor lonafarnib tolerability, especially GI effects.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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