Drug interactions
Lonafarnib + Paliperidone
Severity: Minor
Lonafarnib and Paliperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-glycoprotein inhibitor and may modestly raise paliperidone concentrations. The clinical effect is likely small but could increase dose-related adverse effects.
What this interaction means in plain words
Lonafarnib and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Paliperidone belongs to Central Nervous System.
Why it happens
Weak inhibition of P-glycoprotein-mediated efflux of paliperidone.
What to do
Monitor for sedation, extrapyramidal symptoms and orthostasis, and lower the paliperidone dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Paliperidone?
MediHelp rates the interaction as minor. Lonafarnib and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a weak P-glycoprotein inhibitor and may modestly raise paliperidone concentrations. The clinical effect is likely small but could increase dose-related adverse effects.
How serious is the interaction between Lonafarnib and Paliperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms and orthostasis, and lower the paliperidone dose if adverse effects occur.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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