Drug interactions
Lonafarnib + Pravastatin
Severity: Minor
Lonafarnib and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pravastatin is not a CYP3A inhibitor, so it is not expected to raise lonafarnib exposure. No meaningful interaction is expected.
What this interaction means in plain words
Lonafarnib and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Pravastatin belongs to Cardiovascular.
Why it happens
No established mechanism; pravastatin does not inhibit CYP3A4.
What to do
No adjustment needed; continue routine monitoring of lonafarnib therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Pravastatin?
MediHelp rates the interaction as minor. Lonafarnib and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pravastatin is not a CYP3A inhibitor, so it is not expected to raise lonafarnib exposure. No meaningful interaction is expected.
How serious is the interaction between Lonafarnib and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; continue routine monitoring of lonafarnib therapy.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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