Drug interactions
Lonafarnib + Simvastatin
Severity: Contraindicated
Lonafarnib and Simvastatin: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and is expected to increase simvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Labeling advises against the combination.
What this interaction means in plain words
Lonafarnib and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lonafarnib belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
Why it happens
Lonafarnib strongly inhibits CYP3A4, reducing the metabolism of simvastatin.
What to do
Avoid; stop simvastatin during lonafarnib therapy or use a statin not dependent on CYP3A, monitoring for muscle symptoms.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Simvastatin?
MediHelp rates the interaction as contraindicated. Lonafarnib and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a strong CYP3A inhibitor and is expected to increase simvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Labeling advises against the combination.
How serious is the interaction between Lonafarnib and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; stop simvastatin during lonafarnib therapy or use a statin not dependent on CYP3A, monitoring for muscle symptoms.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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