Drug interactions
Loperamide + Lovastatin
Severity: Minor
Loperamide and Lovastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lovastatin is a weak P-glycoprotein inhibitor in vitro, and any rise in loperamide exposure would be small. Clinical significance is unlikely at normal doses.
What this interaction means in plain words
Loperamide and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loperamide belongs to Gastrointestinal Tract; Lovastatin belongs to Cardiovascular.
Why it happens
Possible weak inhibition of P-glycoprotein efflux of loperamide.
What to do
No routine action is needed beyond using loperamide at labeled doses. Be alert for excess constipation or CNS effects if high loperamide doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loperamide
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Loperamide with Lovastatin?
MediHelp rates the interaction as minor. Loperamide and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lovastatin is a weak P-glycoprotein inhibitor in vitro, and any rise in loperamide exposure would be small. Clinical significance is unlikely at normal doses.
How serious is the interaction between Loperamide and Lovastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed beyond using loperamide at labeled doses. Be alert for excess constipation or CNS effects if high loperamide doses are used.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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