Drug interactions
Loperamide + Osilodrostat
Severity: Moderate
Loperamide and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and loperamide at high doses can do likewise. Combined use may increase risk of ventricular arrhythmia, especially with hypokalemia.
What this interaction means in plain words
Loperamide and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loperamide belongs to Gastrointestinal Tract; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT interval prolongation.
What to do
Keep loperamide within labeled doses, correct potassium and magnesium, and monitor ECG as advised for osilodrostat.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Osilodrostat
Frequently asked questions
Can I take Loperamide with Osilodrostat?
MediHelp rates the interaction as moderate. Loperamide and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and loperamide at high doses can do likewise. Combined use may increase risk of ventricular arrhythmia, especially with hypokalemia.
How serious is the interaction between Loperamide and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep loperamide within labeled doses, correct potassium and magnesium, and monitor ECG as advised for osilodrostat.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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