Drug interactions
Loperamide + Oxaliplatin
Severity: Moderate
Loperamide and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to QT prolongation, and oxaliplatin commonly causes diarrhea, which may lead patients to take loperamide, sometimes at high doses. Electrolyte loss from diarrhea further raises the risk of arrhythmia.
What this interaction means in plain words
Loperamide and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loperamide belongs to Gastrointestinal Tract; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT prolongation, worsened by diarrhea-related hypokalemia and hypomagnesemia.
What to do
Keep loperamide within labeled doses and check potassium and magnesium during chemotherapy-induced diarrhea. Obtain an ECG in patients with additional QT risk factors or heavy loperamide use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Loperamide and Oxaliplatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Loperamide
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Loperamide with Oxaliplatin?
MediHelp rates the interaction as moderate. Loperamide and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to QT prolongation, and oxaliplatin commonly causes diarrhea, which may lead patients to take loperamide, sometimes at high doses. Electrolyte loss from diarrhea further raises the risk of arrhythmia.
How serious is the interaction between Loperamide and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep loperamide within labeled doses and check potassium and magnesium during chemotherapy-induced diarrhea. Obtain an ECG in patients with additional QT risk factors or heavy loperamide use.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
