Drug interactions
Loperamide + Sirolimus
Severity: Minor
Loperamide and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus is a P-glycoprotein substrate and may compete with loperamide for efflux, possibly raising loperamide levels slightly. A meaningful clinical effect is uncertain.
What this interaction means in plain words
Loperamide and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loperamide belongs to Gastrointestinal Tract; Sirolimus belongs to Miscellaneous.
Why it happens
Possible competition for P-glycoprotein efflux.
What to do
No specific adjustment is needed at labeled loperamide doses. Monitor for excess constipation or sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loperamide
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Loperamide with Sirolimus?
MediHelp rates the interaction as minor. Loperamide and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus is a P-glycoprotein substrate and may compete with loperamide for efflux, possibly raising loperamide levels slightly. A meaningful clinical effect is uncertain.
How serious is the interaction between Loperamide and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is needed at labeled loperamide doses. Monitor for excess constipation or sedation.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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