Drug interactions
Loperamide + Solifenacin
Severity: Moderate
Loperamide and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solifenacin can prolong QT at higher exposures, and both drugs reduce gastrointestinal motility. Combination may add to arrhythmia risk and constipation or ileus.
What this interaction means in plain words
Loperamide and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loperamide belongs to Gastrointestinal Tract; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation and additive antimotility or anticholinergic effects.
What to do
Use labeled loperamide doses and monitor for constipation or ileus. Check an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Solifenacin
Frequently asked questions
Can I take Loperamide with Solifenacin?
MediHelp rates the interaction as moderate. Loperamide and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solifenacin can prolong QT at higher exposures, and both drugs reduce gastrointestinal motility. Combination may add to arrhythmia risk and constipation or ileus.
How serious is the interaction between Loperamide and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use labeled loperamide doses and monitor for constipation or ileus. Check an ECG in patients with other QT risk factors.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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