Drug interactions
Loperamide + Vemurafenib
Severity: Moderate
Loperamide and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may increase loperamide exposure, and it also prolongs the QT interval. This combination may add to cardiac risk when loperamide is used at higher doses.
What this interaction means in plain words
Loperamide and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loperamide belongs to Gastrointestinal Tract; Vemurafenib belongs to Oncology.
Why it happens
P-gp inhibition by vemurafenib increases loperamide exposure, with additive QT effects.
What to do
Use the lowest effective loperamide dose and monitor ECG and electrolytes per vemurafenib guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Vemurafenib
Frequently asked questions
Can I take Loperamide with Vemurafenib?
MediHelp rates the interaction as moderate. Loperamide and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-glycoprotein and may increase loperamide exposure, and it also prolongs the QT interval. This combination may add to cardiac risk when loperamide is used at higher doses.
How serious is the interaction between Loperamide and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective loperamide dose and monitor ECG and electrolytes per vemurafenib guidance.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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