Drug interactions
Loperamide + Vorinostat
Severity: Moderate
Loperamide and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and loperamide at high doses can also prolong QT. Combined use may increase arrhythmia risk, and loperamide is often used for vorinostat-related diarrhea.
What this interaction means in plain words
Loperamide and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loperamide belongs to Gastrointestinal Tract; Vorinostat belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Keep loperamide within labeled doses, correct potassium and magnesium, and monitor ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Loperamide with Vorinostat?
MediHelp rates the interaction as moderate. Loperamide and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation, and loperamide at high doses can also prolong QT. Combined use may increase arrhythmia risk, and loperamide is often used for vorinostat-related diarrhea.
How serious is the interaction between Loperamide and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep loperamide within labeled doses, correct potassium and magnesium, and monitor ECG in patients with other QT risk factors.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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