Drug interactions
Lopinavir + Metaxalone
Severity: Moderate
Lopinavir and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, boosted with ritonavir, inhibits CYP3A4 and may raise metaxalone exposure. This may increase drowsiness and dizziness.
What this interaction means in plain words
Lopinavir and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Metaxalone belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated metabolism of metaxalone by the ritonavir component of lopinavir/ritonavir.
What to do
Monitor for excess sedation and dizziness and use the lowest effective metaxalone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Metaxalone?
MediHelp rates the interaction as moderate. Lopinavir and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, boosted with ritonavir, inhibits CYP3A4 and may raise metaxalone exposure. This may increase drowsiness and dizziness.
How serious is the interaction between Lopinavir and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness and use the lowest effective metaxalone dose.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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