Drug interactions
Lopinavir + Mifepristone
Severity: Major
Lopinavir and Mifepristone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir strongly inhibits CYP3A4 and can increase mifepristone exposure, and mifepristone may raise lopinavir levels. Both drugs can prolong the QT interval, increasing arrhythmia risk.
What this interaction means in plain words
Lopinavir and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lopinavir belongs to Anti Virals; Mifepristone belongs to Endocrine.
Why it happens
Mutual CYP3A4 inhibition plus additive QT prolongation.
What to do
Avoid if alternatives exist. If combined, limit mifepristone to 300 mg/day in Cushing syndrome and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Mifepristone?
MediHelp rates the interaction as major. Lopinavir and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir/ritonavir strongly inhibits CYP3A4 and can increase mifepristone exposure, and mifepristone may raise lopinavir levels. Both drugs can prolong the QT interval, increasing arrhythmia risk.
How serious is the interaction between Lopinavir and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist. If combined, limit mifepristone to 300 mg/day in Cushing syndrome and monitor ECG and electrolytes.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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