Drug interactions
Lopinavir + Regorafenib
Severity: Major
Lopinavir and Regorafenib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is coformulated with ritonavir, a strong CYP3A4 inhibitor, which may increase regorafenib exposure with unpredictable metabolite effects.
What this interaction means in plain words
Lopinavir and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lopinavir belongs to Anti Virals; Regorafenib belongs to Oncology.
Why it happens
Ritonavir-boosted lopinavir inhibits CYP3A4 metabolism of regorafenib.
What to do
Avoid if possible; otherwise monitor liver tests and toxicity closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Regorafenib
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Regorafenib?
MediHelp rates the interaction as major. Lopinavir and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir is coformulated with ritonavir, a strong CYP3A4 inhibitor, which may increase regorafenib exposure with unpredictable metabolite effects.
How serious is the interaction between Lopinavir and Regorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor liver tests and toxicity closely.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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