Drug interactions
Lopinavir + Repaglinide
Severity: Moderate
Lopinavir and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, given with ritonavir, inhibits CYP3A4 and may raise repaglinide levels. This can result in prolonged or excessive glucose lowering.
What this interaction means in plain words
Lopinavir and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Repaglinide belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 by the lopinavir/ritonavir combination reduces repaglinide metabolism.
What to do
Monitor blood glucose closely and lower the repaglinide dose if hypoglycemia develops. Review dosing again when the antiretroviral regimen changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Repaglinide?
MediHelp rates the interaction as moderate. Lopinavir and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, given with ritonavir, inhibits CYP3A4 and may raise repaglinide levels. This can result in prolonged or excessive glucose lowering.
How serious is the interaction between Lopinavir and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and lower the repaglinide dose if hypoglycemia develops. Review dosing again when the antiretroviral regimen changes.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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